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Research questions in severe and difficult asthma
Research has identified that much asthma remains uncontrolled in spite of maximal therapy and guideline adherence. Factors responsible for this require elucidation. To date rhinitis and smoking appear to have been identified as significant factors along side poor adherence, although these factors fail to account for all of the poor outcomes found. New therapeutic options including therapies targeting IgE which appear to assist in treating many such patients and when licensed broadly justify study in broad primary care settings.
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